http://nopr.niscpr.res.in/handle/123456789/66985 Sat, 10 Oct 2026 20:50:18 GMT 2026-10-10T20:50:18Z http://nopr.niscpr.res.in/handle/123456789/66992 Title: Synthesis of α-hydroxy, β-bromo-exo-dicyclopentadiene-1-one: A new building block for cyclopentanoids Authors: Kotha, Sambasivarao; Reddy Keesari, Ramakrishna Abstract: Herein, we described a simple synthetic strategy for the preparation of α-hydroxy, β-bromo-exo-dicyclopentadiene-1-one by following a three-step sequence. The synthetic strategy relies on operationally simple reactions and high yielding steps. The newly synthesized compounds have been characterized by NMR. As the disclosed compound α-hydroxy, β-bromo-exodicyclopentadiene- 1-one is highly functionalized but structurally similar to exo-dicyclopentadiene-1-one and it can be used a key building block for expanding the chemical space of cyclopentanoid derivatives. Page(s): 1127-1132 Mon, 01 Dec 2025 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/66992 2025-12-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/66991 Title: Lewis acid-promoted synthesis of 3-tosylisoindolinone from 3-hydroxyisoindolinone: Access to complex furopyrroloisoindoledione Authors: Das, Malay; Kumar, Virendra; Jyoti Arandhara, Pallav; Biswas, Subhamoy; K Saikia, Anil Abstract: An efficient methodology has been developed for the synthesis of sulfur-functionalized isoindolone scaffold from hydroxyisoindolinone via N-acyliminium ion intermediate using TosMIC and Lewis acid in good to excellent yields. The strategy features mild reaction conditions, broad substrate scope and metal-free reaction method. The protocol has been extended for the synthesis of complex furopyrroloisoindoledione derivatives. Page(s): 1133-1143 Mon, 01 Dec 2025 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/66991 2025-12-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/66990 Title: Antituberculosis activity of α-aminoacyl amide derivatives Authors: B Makane, Vitthal; U Sinde, Akash; Angayarkanni, B; Malik, Pradip; Chopra, Sidharth Abstract: The preparation and evaluation of α-aminoacyl amide derivatives against M. tuberculosis H37Rv is reported. The systematic modifications of hit compounds have been carried out. Compounds 19b and 19c are identified as potent and selective inhibitors of M. tuberculosis H37Rv with MIC 2.5 μM and 2.6 μM, respectively. Compounds 19b and 19c hold a promise for further development to discover new potent antituberculosis leads. Page(s): 1144-1155 Wed, 01 Jan 2025 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/66990 2025-01-01T00:00:00Z http://nopr.niscpr.res.in/handle/123456789/66989 Title: Esterification of levulinic acid with alcohol catalyzed by hierarchically porous ZSM-5 zeolites: A study on catalyst efficiency and product selectivity Authors: Manikandan, K; Shalini, A; Deepa, K; Kaladevi, G; Valarmathi, N; Muthuvel, I; Thirunarayanan, G Abstract: This study evaluates the catalytic performance of ZSM-5 zeolites synthesized using corn stem pith powder as a hard template in the esterification of levulinic acid with 1-proponal and heptanol. The structural and textural properties of the zeolites have been characterized, revealing a hierarchical porous nature. The catalytic activity of the ZSM-5 is assessed in the esterification of levulinic acid with 1-propanol and heptanol, yielding corresponding esters with high selectivity. The effects of reaction parameters, including temperature, molar ratio, catalyst loading, and reaction time, are systematically studied to optimize reaction conditions. The reusability and stability of the catalyst are evaluated through multiple reaction cycles. The results are compared with those obtained using conventional ZSM-5, highlighting the advantages of the meso porous structure. This study provides valuable insights into the design of hierarchical zeolite catalysts for green and sustainable chemistry applications. The use of corn stem pith powder as a hard template enhances the textural properties of the zeolite while promoting sustainability and resource efficiency. Page(s): 1156-1163 Wed, 01 Jan 2025 00:00:00 GMT http://nopr.niscpr.res.in/handle/123456789/66989 2025-01-01T00:00:00Z