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http://nopr.niscpr.res.in/handle/123456789/10080| Title: | Synthesis and biological activity of novel 2,5-disubstituted-1,3,4-oxadiazoles |
| Authors: | Shailaja, M Anitha, M Manjula, A Rao, B Vittal |
| Keywords: | 1,3,4-Oxadiazoles;chloramine-T;oxidative cyclization;halopyridines |
| Issue Date: | Aug-2010 |
| Publisher: | CSIR |
| Abstract: | A new and previously unreported molecular
framework of 1,3,4-oxadiazoles incorporating halo pyridines has been
synthesised. The derivatives are synthesised starting from substituted
pyridinyloxy benzaldehydes, by converting them in to corresponding arylidene
hydrazides followed by chloramine-T oxidation to the title compounds. The
2,5-disubstituted 1,3,4-oxadiazole derivatives are tested for antimicrobial activity.
Many compounds showed high degree of activity against Staphylococus aureus and Escherichia
coli bacteria at 250  g/mL concentration. |
| Page(s): | 1088-1097 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.49B(08) [August 2010] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 49B(8) 1088-1097.pdf | 130.06 kB | Adobe PDF | View/Open |
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