Antinociceptive activity of chronic administration of different extracts of <i style="">Terminalia bellerica Roxb. </i>and <i style="">Terminalia chebula Retz. </i>fruits

Abstract

The petroleum ether (PE), chloroform (CH), ethanol (ETH) and water extracts of <i style="">Terminalia bellerica</i> and <i style="">T. chebula</i> fruits were evaluated for their analgesic activity using the tail immersion model in mice. The ethanolic extracts of both the plants exhibited analgesic response at 200,400 and 800mg/kg. The studies were further carried for 15 days to evaluate the effect of these extracts in chronic pain and maximum analgesic response was observed on 14^th day in both the plants. Phytochemical investigation of ethanolic extract of the fruits of <i style="">Terminalia bellerica</i> and <i style="">T. chebula</i> revealed the presence of saponins, triterpenoids, carbohydrates, tannins and proteins. The results indicate that fruits of <i style="">T. bellerica</i> and <i style="">T. chebula</i> could be considered as potential candidate for bioactivity-guided isolation of natural analgesic agents used in the management of chronic pain.