Please use this identifier to cite or link to this item:
Title: Antioxidant and hepatoprotective activity of Aphanizomenon flos-aquae Linn against paracetamol intoxication in rats
Authors: Kuriakose, Gini C
Kurup, Muraleedhara G
Keywords: Antioxidants;Aphanizomenon flos-aquae;Hepatoprotection;Paracetamol;Reactive oxygen species
Issue Date: Nov-2010
Publisher: NISCAIR-CSIR, India
Abstract: Paracetamol caused liver damage as evident by significant increase in the activities of aspartate and alanine transferases. There were general statistically significant losses in the activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione transferase and an increase in thiobarbituric acid reactive substances in the liver of paracetamol treated group compared with the control group. However, treatment with ethanol extract of A. flos-aquae (EEAFA) was able to counteract these effects. Protection offered by silymarin (standard reference drug) seemed relatively greater. The results suggest that EEAFA can act as hepatoprotective agent against paracetamol induced toxicity as an antioxidant.
Page(s): 1123-1130
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.48(11) [November 2010]

Files in This Item:
File Description SizeFormat 
IJEB 48(11) 1123-1130.pdf212.46 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.