Condensed bridgehead nitrogen heterocyclic systems: Microwave assisted synthesis and bioactivity of <i>s</i>-triazolo[3,4- ][1,3,4]thiadiazoles, <i>s</i>-triazolo[3,4- ][1,3,4]thiadiazines and <i>s</i>-triazolo [3' ,4' :2,3]-thiadiazino[5,6- ]quinoxaline

Abstract

N-[3-(4-Amino-5-mercapto-4 -[1,2,3]triazol-3-yl)-4,5,6,7-tetrahydrobenzo[ ] thiophen-2-yl]acetamide 1 on condensation with chloroac etic acid, -haloketone and benzoin furnishes [1,2,4]triazolo[3,4- ][1,3,4]thiadiazine derivatives 2,3 and 4 respectively, while condens ation with 2,3-dichloroquinoxaline, carbon disulphide, aromatic c arboxylic ac id and aromatic carboxaldehydes yield the cyclic products, [1,2,4] triazolo[3,4- ][1,3,4]thiadiazole derivatives 5, 6, 7,8 respectively. The compounds have been characterized on the basis of elemental analysis and spectral data. The antibacterial, antifungal and antitubercular activities of the compounds have also been evaluated.