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http://nopr.niscpr.res.in/handle/123456789/10650| Title: | Oily fraction of Semecarpus anacardium Linn nuts involves protein kinase C activation for its pro-inflammatory response |
| Authors: | Tripathi, Yamini B Pandey, Nidhi Tripathi, Deepshikha Tripathi, Pratibha |
| Issue Date: | Dec-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The oily fraction (non polar fraction-NPF) of S. anacardium (SA) significantly increased the expression of protein kinase C-δ (PKC-δ) in macrophages in concentration dependent manner, which was similar to phorbol myristate acetate (PMA) response. Further, H-7 (1-(5-isoquinolinesulphonyl)-2-methylpiperazine), an inhibitor of PKC significantly inhibited this NPF mediated response in a concentration dependent manner. In the post treatment kinetics, H-7 showed this inhibition only up to 6 min post NPF/PMA addition, but in similar condition, quercetin, a flavone with reported antioxidant property, showed this inhibition only up to 2 min. The results clearly suggest that oily fraction of SA nuts enhances the expression of PKC protein, which may be responsible for its reported pro-inflammatory property. |
| Page(s): | 1204-1209 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.48(12) [December 2010] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 48(12) 1204-1209.pdf | 900.29 kB | Adobe PDF | View/Open |
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