Facile one-pot synthesis of novel 3-substituted-1, 6-dihydro-1,2,4-triazin-5-(2<i style="">H</i>)-ones from fatty acid hydrazides and their <i style="">in-vitro</i> antimicrobial activity

Abstract

A series of 3-substituted-1,6-dihydro-1,2,4-triazin-5(2<i style="">H</i>)-ones, have been synthesized using the cyclocondensation reaction of fatty acid hydrazides with 2-chloroacetamide in N,N-dimethylformamide medium. The structural elucidation of the synthesized compounds is based on IR, ¹H NMR, mass spectral data and elemental analysis. These compounds have been tested for their <i style="">in-vitro</i> antibacterial and antifungal activities. The MIC, MBC and MFC have also been determined.