Codon usage pattern of differentially expressed genes in <i style="">Leishmania </i>species

Abstract

Out of numerous genes, differentially expressed genes of <i style="">Leishmania major </i>(299) and <i style="">L. infantum</i> (241), essential for their survival, have been studied for the analysis of synonymous codon usage patterns. The role of translational selection and mutational biases were analyzed through ENc plot and correspondence analysis. Present analysis indicates that mutational pressure has a profound effect on codon usage pattern in both the species of <i style="">Leishmania</i> (with a minor variation). Beside this, natural and translational selections also operate with a proper balance that makes the organism translationally more efficient.