Neuroprotective potential of ethanolic extract of<i style=""> Pseudarthria viscida </i>(L) Wight and Arn<i style=""> </i>against <img src='/image/spc_char/beta.gif' border=0>-amyloid_(25-35)-induced amnesia in mice

Abstract

The neuroprotective potential of ethanolic extract of roots of <i style="">Pseudarthria viscida</i> (L) Wight and Arn (EEPV) was investigated against <img src='/image/spc_char/beta.gif' border=0>-amyloid_(25-35)-induced amnesia in mice which is a suitable animal model for Alzheimer’s disease (AD). The senile plaques of <img src='/image/spc_char/beta.gif' border=0>-amyloid (A<img src='/image/spc_char/beta.gif' border=0>) are major constituents accumulated during the progression of AD as a potent neurotoxicant. In our investigation, intracerebroventricular injection of A<img src='/image/spc_char/beta.gif' border=0>_(25-35) in mice induced the neurodegeneration, exhibited the increased time of escape latency in behavioral pattern using water maze and decreased the levels of antioxidants namley superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and vitamin C with elevated level of acetylcholinesterase enzyme (AChE). The neuroprotective potential of EEPV was determined by behavioral pattern using water maze and biochemical parameters such as SOD, CAT and GPx and vitamin C content as well as AChE. Mice were treated with EEPV at 200 and 400 mg/kg doses for 21 days. Except control, all animals received a single injection of neurotoxicant A<img src='/image/spc_char/beta.gif' border=0>_(25-35)on 14^th day. In behavioural assessment, treatment with ethanolic extract improved the cognitive function in the water maze and attenuated the elevated levels of AChE with increase in antioxidant enzymes, indicating the neuroprotection with increased levels of vitamin C. These findings suggest that ethanolic extract of <i style="">P. viscida </i>exerts anti-amnesiac effects and enhances cognitive function.