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Title: Anti-depressant-like activity of a novel serotonin type-3 (5-HT3) receptor antagonist in rodent models of depression
Authors: Gupta, Deepali
Devadoss, Thangaraj
Bhatt, Shvetank
Gautam, Baldev
Jindal, Ankur
Pandey, Dilip
Mahesh, Radhakrishnan
Keywords: Anti-depressant-like effect;Depression;Forced swim test;5-HT3 antagonist;Quinoxalin-2-carboxamide;Serotonin
Issue Date: Aug-2011
Publisher: NISCAIR-CSIR, India
Abstract: N-Cyclohexyl-3-methoxyquinoxalin-2-carboxamide (QCM-13), a novel 5-HT3 antagonist identified from a series of compounds with higher pA2 (7.6) and good log P (2.91) value was screened in rodent models of depression such as forced swim test (FST), tail suspension test (TST), interaction studies with standard anti-depressants and confirmatory studies such as reversal of parthenolide induced depression and reserpine induced hypothermia. In FST (2 and 4 mg/kg) and TST (2 and 4 mg/kg), QCM-13 significantly reduced the duration of immobility in mice without affecting the base line locomotion. QCM-13 (2 and 4 mg/kg) was also found to have significant interaction with standard anti-depressants (fluoxetine and bupropion in FST and TST respectively). Further, reversal of parthenolide induced depression in mice and reserpine induced hypothermia in rat models indicate the serotonergic influence of QCM-13 for anti-depressant potential.
Page(s): 619-626
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.49(08) [August 2011]

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