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http://nopr.niscpr.res.in/handle/123456789/12674| Title: | Synthesis and biological evaluation of Mannich bases of benzimidazole derivatives |
| Authors: | Mariappan, G Bhuyan, N R Kumar, Pradeep Kumar, Deepak Murali, K |
| Keywords: | Benzimidazole;Analgesic;Anti-inflammatory;Mannich bases |
| Issue Date: | Sep-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | [1-(N-substituted amino) methyl]-2-ethyl benzimidazole derivatives 1-10 have been synthesized by the condensation of 2-ethyl benzimidazole with substituted primary and secondary amines. Their structures have been elucidated by UV-Vis, IR, 1H NMR and mass spectral data. Among the synthesized derivatives 1, 2, 8, 9 and 10 are found to have an effective anti-inflammatory response whereas compounds 2, 4, 6, 8 and 10 have potent analgesic response. There is no significant difference in bioactivity of benzimidazoles derived from secondary and primary amines. All the experimental data were statistically significant at P<0.05 level. |
| Page(s): | 1216-1219 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.50B(09) [September 2011] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 50B(9) 1216-1219.pdf | 64.88 kB | Adobe PDF | View/Open |
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