Anti-inflammatory and analgesic activities of <i>Dashana Samskara Churna</i> and its paste form

Abstract

Anti-inflammatory and analgesic activities of <i style="">Dashana Samskara Churna</i><b style=""> </b>and its paste form were<b style=""> </b>examined in different animal models. Anti-inflammatory activity was evaluated in acute, sub-acute and chronic inflammatory models and compared with Phenylbutazone, Diclofenac sodium and Dexomethasone standards, respectively. Analgesic activity was evaluated in formalin induced paw licking (chemically induced pain) and tail flick method (thermally induced pain) where Indomethacin and Pentazocine were used as standard drugs, respectively. Test formulation in the form of paste inhibited the carrageenan induced paw oedema (<i>P<</i>0.05), formalin induced paw licking (<i>P<</i>0.01) and increased the Tail Flick Latency (<i>P<</i>0.05) in comparison to control rats. Test formulation in the form of <i>Churna</i> did not inhibit the paw oedema induced by phlogostic agents, however it exhibited significant analgesic activity by decreasing formalin induced paw licking response (<i>P<</i>0.05). The results suggest that the paste form of <i style="">Dashana Samskara Churna</i> has significant analgesic and anti-inflammatory potential as reflected by the parameters investigated, while <i>Churna</i> form has only analgesic activity. Thus, it can be concluded that <i style="">Dashana Samskara Churna </i>in the form of paste will be the most appropriate modality in treatment of gingivitis.