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Title: Evaluation of adaptogenic activity profile of a compound Ayurvedic formulation - Amalakayas Rasayana
Authors: Samarakoon, SMS
Chandola, HM
Ravishankar, B
Ashok, BK
Gupta, Varun B
Keywords: Amalakayas Rasayana;Adaptogenic activity;Ghrita;Madhu;Ulcer index
Issue Date: Oct-2011
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8: H01R 25/00, G0L 1/00, A01D 20/48, A01D 20/76, A01D 7/12, A01D 4/52
Abstract: The present study was undertaken to evaluate adaptogenic activity profile of a classical compound Ayurvedic formulation Amalakayas Rasayana in experimental animals. Amalakayas Rasayana (AR) was tested for its adaptogenic activity by determining anti-stress and anti-ulcer activity in forced swimming induced hypothermia and stress induced gastric ulcers. AR was administered in the dose of 270 mg/kg orally for 7 consecutive days prior to forced swimming induced hypothermia and stress ulcers. The adaptogenic and anti-ulcer activities were assessed by determining and comparing the changes in rectal temperature, ponderal changes, ulcer index, haematological parameters and anti-oxidant activity in the test drug group with that of stress control group as well as vehicle control group. In forced swimming hypothermia pre-treatment with AR caused significant attenuation of rectal temperature when compared with both stress control and vehicle control groups. It has shown a significant reduction in ulcer index and lipid peroxidation. Moreover, AR did show a significant increase in total glutathione content. The results suggest that AR possesses significant adaptogenic and anti-stress activity which could be either due to attenuation of stress induced stimulation of HPA axis and cytoprotective action of the test formulation.
Page(s): 661-667
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.10(4) [October 2011]

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