Effect of oleo-gum-resin of <i>Boswellia serrata </i>(<i style="">Kundur</i>) on renal functions in Albino rats

Abstract

Oleo-gum-resin of <i>Boswellia serrata</i> Roxb. (Burseraceae) locally called ‘<i style="">Kundur’</i>, is one of the ingredients in certain Unani formulations used in renal diseases. In the present study, the effect of <i style="">Kundur</i> and its methanol soluble (MS), and methanol insoluble (MINS) fractions were investigated on Gentamicin induced nephrotoxicity in Albino rats. The renal effects of <i style="">Kundur</i> and its fractions were studied by monitoring urea and creatinine blood levels.

Aminoglycoside antibiotics including Gentamicin are widely used in the treatment of Gram-negative bacterial infections. A major complication of the use of these drugs is nephrotoxicity. In the current study, treatment with <i style="">Kundur</i> its methanol soluble (MS) and methanol insoluble (MINS) fractions significantly prevented the rise in blood urea and serum creatinine levels. Our results suggest that <i style="">Kundur</i> and its (MS) methanol soluble fraction induced renoprotective action against Gentamicin induced nephrotoxicity probably due to the presence of compounds possessing antioxidant potential.