Sodium selenite attenuated cisplatin-induced toxicity in rats: Role of electrolytes homeostasis

Abstract

Sodium selenite (1 mg/kg body weight, ip) for 10 consecutive days treatment showed marked increase in intra-erythrocytes K⁺ and plasma Na⁺ level while slight increase in Na⁺K⁺ ATPase level. No mortality was observed at this dose of sodium selenite. However, sodium selenite pretreatment partially restored the Na⁺ K⁺ ATPase and intra-erythorcytes and plasma sodium level, while completely restored the intra-erythrocytes K⁺and plasma Mg²⁺level. No change was observed in plasma Ca²⁺ level. Thus sodium selenite successively attenuated the Cisplatin-induced electrolytes alterations and toxicity by exerting the stress response of sodium.