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Title: Microwave assisted synthesis of some novel pyrazole substituted benzimidazoles and evaluation of their biological activities
Authors: Kalirajan, R
Rathore, Leela
Jubie, S
Gowramma, B
Gomathy, S
Sankar, S
Keywords: Benzimidazoles;Pyrazoles;Anticancer;Antimicrobial;Antitubercular;Microwave irradiation
Issue Date: Dec-2011
Publisher: NISCAIR-CSIR, India
Abstract: A series of novel and significant compounds containing pyrazole substituted benzimidazoles 4a-h and 5a-h have been synthesized from o-phenylenediamine under microwave irradiation. The structures of the newly synthesized compounds have been confirmed on the basis of elemental analysis and spectral data. Some of the synthesized compounds 4b, 4h, 5d, 5f exhibit significant antibacterial activity. The compounds 5b, 5f exhibit good antifungal activity. Compounds 5a and 5b have shown good anticancer activity and the compound 4a exhibits significant anti tubercular activity.
Page(s): 1794-1799
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(12) December 2011]

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