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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lee, Jung Hun | - |
| dc.contributor.author | Sohn, Seung Ghyu | - |
| dc.contributor.author | Jung, Ha Il | - |
| dc.contributor.author | An, Young Jun | - |
| dc.contributor.author | Lee, Jae Jin | - |
| dc.contributor.author | Kang, Lin-Woo | - |
| dc.contributor.author | Lee, Sang Hee | - |
| dc.date.accessioned | 2011-12-23T10:32:00Z | - |
| dc.date.available | 2011-12-23T10:32:00Z | - |
| dc.date.issued | 2011-12 | - |
| dc.identifier.issn | 0975-0959 (Online); 0301-1208 (Print) | - |
| dc.identifier.uri | http://hdl.handle.net/123456789/13255 | - |
| dc.description | 395-398 | en_US |
| dc.description.abstract | OXA-23, a class D carbapenemase that confers widespread antibiotic resistance hydrolyzes the β-lactam rings of β-lactam antibiotics, presenting an enormous challenge to infection control, particularly in the eradication of pathogenic bacteria such as Acinetobacter baumannii, one of six top-priority dangerous pathogens. Thus, the enzyme is a potential target for developing antimicrobial agents against pathogens producing carbapenemases. In this study, OXA-23 was purified and crystallized at 298 K and X-ray diffraction data from OXA-23 crystal were collected at 2.03 Å resolution using synchrotron radiation. The crystal of OXA-23 belonged to space group P41 with unit cell parameters a = 82.47, b = 82.47 and c = 172.01 Å. Analysis of the packing density showed that the asymmetric unit probably contained two molecules with a solvent content of 73.64%. | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | NISCAIR-CSIR, India | en_US |
| dc.rights |  CC Attribution-Noncommercial-No Derivative Works 2.5 India | en_US |
| dc.source | IJBB Vol.48(6) [December 2011] | en_US |
| dc.subject | Antibiotic resistance | en_US |
| dc.subject | Imipenem | en_US |
| dc.subject | Crystal | en_US |
| dc.subject | OXA-23 | en_US |
| dc.subject | Carbapenemase | en_US |
| dc.subject | Acinetobacter baumannii | en_US |
| dc.title | Preparation, crystallization and preliminary X-ray crystallographic analysis of OXA-23, a carbapenemase conferring widespread antibiotic resistance | en_US |
| dc.type | Article | en_US |
| Appears in Collections: | IJBB Vol.48(6) [December 2011] | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJBB 48(6) 395-398.pdf | 405.99 kB | Adobe PDF | View/Open |
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