Synthesis and anticancer activity of 3,5-diaryl-1,2,4-oxadiazole derivatives

Abstract

3,5-Diaryl-1,2,4-oxadiazole derivatives are synthesized by condensation reaction of amidoximes with aromatic acid chloride. Amidoximes are obtained from aromatic nitriles and acid chlorides from corresponding aromatic monocarboxylic acid derivatives. There are broad possibilities of preparing several such compounds in this series by using different aromatic nitriles as well as different aromatic monocarboxylic acid derivatives. The synthesized compounds are evaluated for their anticancer activity by using mice specific Ehrlich Ascites Carcinoma cell (EAC cells) in Swiss albino mice model. Synthesized compounds (dose 25 mg/kg body weight) show significant reduction of tumor cell count as well as tumor weight. Life span of the treated mice also increases. The standard drug used for the study is 5-fluorouracil (5 mg/kg body weight).