Calcium alginate/PVA blended nano fibre matrix for wound dressing

Abstract

The nanocomposite web of calcium alginate and polyvinyl alcohol with varying proportion has been prepared by electrospinning and its application for wound healing is examined. Scanning electron microscope and Fourier transform infrared spectroscopy have been used to characterize the morphology and molecular fingerprint. The water vapour transmission rate of the blended nanofibre composite web having maximum calcium alginate content is found to be 2725.8 g/m²/2h, which helps in maintaining a moist environment over the wound surface. The wound healing capacity of the nanofibre has been evaluated using a rat model. When the wound is covered with nanofibre, it forms gel due to the presence of calcium alginate and filled with new epithelium without any harmful reactions.