Development and characterization of cotton and organic cotton gauze fabric coated with biopolymers and antibiotic drugs for wound healing

Abstract

The present work deals with the development and characterisation of cotton and organic cotton based bandage using 40^s Ne yarn. The physical properties such as areal density, air permeability and stiffness of fabrics have been measured. Chitosan-sodium alginate polymer, calcium-sodium alginate polymer and their mixture have been coated separately on the gauze structure to improve its antibacterial and wound healing property. The drugs such as tetracycline hydrochloride (250 mg), chloramphenicol (250 mg) and rifampin (250 mg) have been immobilized on the polymer coated fabrics to increase the rate of wound healing and antibacterial activity. Further, the antibacterial activity of the drug loaded and polymer coated samples has been evaluated against <i style="">S.aureus</i> and <i style="">Proteus</i> bacteria. The results show excellent antibacterial activity.