An improved and scalable process for the synthesis of a key intermediate for Etodolac, a non-steroidal anti-inflammatory drug

Sekharayya, M Chandra; Narayana, G Venkata; Nigam, Satish; Madhusudhan, G

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Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/15197

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DC Field	Value	Language
dc.contributor.author	Sekharayya, M Chandra	-
dc.contributor.author	Narayana, G Venkata	-
dc.contributor.author	Nigam, Satish	-
dc.contributor.author	Madhusudhan, G	-
dc.date.accessioned	2012-12-08T15:54:14Z	-
dc.date.available	2012-12-08T15:54:14Z	-
dc.date.issued	2012-12	-
dc.identifier.issn	0975-0983(Online); 0376-4699(Print)	-
dc.identifier.uri	http://hdl.handle.net/123456789/15197	-
dc.description	1763-1766	en_US
dc.description.abstract	An improved and scalable method is developed for the synthesis of 7-ethyltryptophol, a key intermediate for Etodolac, a non-steroidal anti-inflammatory drug (NSAID) starting from commercially available 2-ethylphenyl hydrazine and dihydrofuran with H₂SO₄ as a catalyst in N,N-dimethylacetamide (DMAc)-H₂O (1:1) as a solvent in 69% yield. The method is easy, inexpensive and reproducible and the process is clean, high yielding and operationally simple.	en_US
dc.language.iso	en_US	en_US
dc.publisher	NISCAIR-CSIR, India	en_US
dc.rights	CC Attribution-Noncommercial-No Derivative Works 2.5 India	en_US
dc.source	IJC-B Vol.51B(12) December 2012]	en_US
dc.subject	Etodolac	en_US
dc.subject	7-Ethyltryptophol	en_US
dc.subject	2-Ethylphenyl¬hydrazine hydrochloride	en_US
dc.subject	Anti-inflammatory drug N,N-dimethylacetamide	en_US
dc.title	An improved and scalable process for the synthesis of a key intermediate for Etodolac, a non-steroidal anti-inflammatory drug	en_US
dc.type	Article	en_US
Appears in Collections:	IJC-B Vol.51B(12) December 2012]

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