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http://nopr.niscpr.res.in/handle/123456789/15298| Title: | Effect of metal ions on binding of bilirubin to erythrocyte membranes |
| Authors: | Ali, Mohammad K Tayyab, Saad |
| Issue Date: | Aug-2001 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Binding of bilirubin to different erythrocyte membranes, namely, human, buffalo, sheep and goat, pre-incubated with different concentrations of metal ions was studied. The results showed that among the different metal ions used, Ca2+ had the highest potential in increasing the amount of bound bilirubin followed by Sr2+ and Mg2+, whereas Ba2+ had the lowest potential. Treatment of these membranes with Ca2+ led to an increase in the amount of bound bilirubin in all membranes. However, human erythrocyte membranes pretreated with Ca2+, bound the highest amount of bilirubin compared to other erythrocyte membranes. Increase in bilirubin binding upon Ca2+ -treatment can be ascribed to shielding effect, redistribution of phospholipids as well as increase in surface hydrophobicity induced by Ca2+ . |
| Page(s): | 230-234 |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Appears in Collections: | IJBB Vol.38(4) [August 2001] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJBB 38(4) 230-234.pdf | 1.17 MB | Adobe PDF | View/Open |
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