Hyperlipidemia and Type-I-5' –monodeiodinase activity: Regulation by selenium supplementation

Abstract

<span style="font-size:14.0pt;font-family:" times="" new="" roman";="" mso-fareast-font-family:"times="" roman";mso-ansi-language:en-us;mso-fareast-language:="" en-us;mso-bidi-language:ar-sa"="">Effect of feeding high fat diet (HFD) and selenium supplemented high fat diet for three months on Type-I 5' monodeiodenase &nbsp;(5'-DI) activity in rats was studied. There was significant increase in serum cholesterol and triglyceride levels in HFD fed group as compared to the control and when compared to that of Se supplemented group. HFD feeding resulted in decreased serum Se levels but supplementation of Se with HFD resulted in increase in serum Se. Se-dependent glutathione peroxidase (GSH-Px) activity in liver and aorta increased significantly in HFD fed animals and showed additional significant increase on Se supplementation. In HFD fed group, decrease in the low density lipoprotein (LDL) receptor levels was found whereas in the Se-supplemented HFD group the LDL levels were normal. Both serum T₃ and T_{4 &nbsp;}levels decreased significantly on HFD feeding. However, on supplementation of Se to HFD, significant increase in T₃ and T₄ was observed. The activity of 5'-DI in liver decreased significantly in HFD group, but increased in both liver and aorta in Se supplemented HFD group whereas the reverse was true in thyroid.</span>