Effect of <span style="font-size:14.0pt; font-family:HiddenHorzOCR;mso-bidi-font-family:HiddenHorzOCR">tri-iodothyronine and di-iodothyronine on lipid metabolism <span style="font-size:14.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:EN-US; mso-bidi-language:AR-SA">in a teleost <i>Anabas testudineus </i>Bloch</span></span>

Abstract

Intra-muscular injection of two doses of tri-iodothyronine (T₃) and di-iodothyronine (T₂) ( 100 ng and 200 ng) in female <i>Anabas testudineus </i>for a period of five days had a dose dependent effect on plasma T₃ level, increase in the activity of malic enzyme (ME) in liver and decrease in 6-phosphogluconate dehydrogenase (6-PGDH) while there was no change in isocitrate dehydrogenase (ICDH) and glucose 6- phosphate dehydrogenase (G6PDH) activity. H/M ratio decreased only by high doses of &nbsp;T₃ and T₂ indicating increased HMG CoA reductase activity. In cardiac tissue the activity of ICDH decreased while ME activity was unaltered. Lipid analysis showed increased catabolism of cholesterol to free fatty acids. These &nbsp;observation indicate that like T₃, T₂, a product formed by the monodeiodination of thyroid hormones, is also capable of causing lipid

metabolism in this teleost.