Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/15424| Title: | Modulation of mRNA levels of liver arginase by insulin and vanadate in experimental diabetes |
| Authors: | Salimuddin Upadhyaya, Kailash C Raju, Jayadev Baquer, Najma Z |
| Issue Date: | Apr-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | This work was carried out to study the modulation of arginase expression in experimental diabetes. Here, we have demonstrated that liver arginase activity and mRNA levels increased significantly in diabetic condition. Insulin treatment reverses the increased activity and mRNA levels nearly to the control values. The reversal effects of vanadate are found to be similar to that of insulin and this observation further reiterates the insulin-like effects of vanadate. ELISA and slot blot assay observations are consistent with biochemical measurements of enzyme activity. These results show an increase in arginase activity and mRNA levels in diabetes and decrease in treated animals may be due to the transcriptional regulation of arginase gene. |
| Page(s): | 125-128 |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Appears in Collections: | IJBB Vol.36(2) [April 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJBB 36(2) 125-128.pdf | 869.24 kB | Adobe PDF | View/Open |
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