Induction of apoptosis in AK-5 cells by rotenone involves participation of Caspases

Khar, Ashok; Ali, A Mubarak; Begum, Zareena; Pardhasaradhi, B V V; Varalakshmi, Ch

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Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/15431

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DC Field	Value	Language
dc.contributor.author	Khar, Ashok	-
dc.contributor.author	Ali, A Mubarak	-
dc.contributor.author	Begum, Zareena	-
dc.contributor.author	Pardhasaradhi, B V V	-
dc.contributor.author	Varalakshmi, Ch	-
dc.date.accessioned	2012-12-31T19:09:46Z	-
dc.date.available	2012-12-31T19:09:46Z	-
dc.date.issued	1999-04	-
dc.identifier.issn	0975-0959 (Online); 0301-1208 (Print)	-
dc.identifier.uri	http://hdl.handle.net/123456789/15431	-
dc.description	77-81	en_US
dc.description.abstract	AK-5 tumour cells undergo apoptosis after treatment with rotenone an electron transport inhibitor and oligomycin which inhibits mitochondrial ATPases. Apoptotic process involves the induction of caspases 2 and 3, whereas caspase 1 does not seem to be participating in rotenone/oligomycin induced apoptosis.DEVD which is a specific inhibitor of caspase 3, inhibited apoptosis in AK-5 cells. We have also observed a significant lowering of intracellular pH in AK-5 cells which are induced into the apoptotic process by rotenone. These results suggest an important role for mitochondrial electron transport in the induction of apoptosis in AK-5 tumour cells.	en_US
dc.language.iso	en_US	en_US
dc.publisher	NISCAIR-CSIR, India	en_US
dc.rights	CC Attribution-Noncommercial-No Derivative Works 2.5 India	en_US
dc.source	IJBB Vol.36(2) [April 1999]	en_US
dc.title	Induction of apoptosis in AK-5 cells by rotenone involves participation of Caspases	en_US
dc.type	Article	en_US
Appears in Collections:	IJBB Vol.36(2) [April 1999]

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