<span style="font-size:11.0pt;mso-bidi-font-size: 10.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Phytochemical and pharmacological investigations on aerial parts of <i style="mso-bidi-font-style:normal">Nelumbo nucifera</i> Gaertn. for haematopoietic activity</span>

Abstract

The aim of the study was to investigate effect of ethanolic extract of aerial parts of <i style="mso-bidi-font-style: normal">Nelumbo nucifera </i>Gaertn. (Indian Lotus) on haematological parameters in anaemic rats.<b> </b><span style="mso-bidi-font-weight:bold">Haematopoietic activity of ethanolic extract of aerial part of plant was performed using cyclophosphamide (CP) at the dose of 0.3 mg/kg body weight i.p. and haloperidol (HP) at the dose of 0.2 mg/kg body weight induced aplastic and iron deficiency anaemia in rats, respectively. A morphological study of blood cells was performed along with phytochemical screening and iron estimation of extract by qualitative test and spectrophotometric method. The results of evaluation of the haematopoietic activity induced by cyclophosphamide and haloperidol showed that the plant extract diminish the activity of cyclophosphamide and haloperidol at the 200 mg/kg dose. Qualitative test of extract indicated the presence of alkaloids, flavonoids, phenolic compounds, steroids, carbohydrates, protein and iron. Iron content was estimated by using spectrophotometric method. The data from results supports the use of<b style="mso-bidi-font-weight:normal"> </b><i style="mso-bidi-font-style:normal"><span style="mso-bidi-font-weight:bold">N. nucifera </span></i><span style="mso-bidi-font-weight:bold">Gaertn. in traditional medicine for their haematopoietic activity.

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