<span style="font-size:11.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-bidi-font-family: Mangal;mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language: HI" lang="EN-GB">Role of <i>Tridax procumbens</i> Linn. in the management of experimentally induced urinary calculi and oxidative stress in rats</span>

Abstract

Renal calculi formation is one of the common urological disorders. Hyperoxaluria and hypercalciuria are reported to be major risk factors for renal stone formation. Studies show that exposure to oxalate is toxic to renal epithelial cells and results in oxidative stress. In the present study, ethanolic extract of whole plant of <i>Tridax procumbens</i> Linn. was evaluated for antiurolithiatic activity against 0.75% v/v ethylene glycol and 2% w/v ammonium chloride induced calcium oxalate renal stones and also for antioxidant activity against hyperoxaluria promoted oxidative stress in male albino rats. In the control rats, ethylene glycol and ammonium chloride administration resulted in increased urinary calcium, oxalate and creatinine and renal deposition of calcium and oxalate. Significant increase in oxidative stress was also observed. Histopathology of kidneys revealed many calcium oxalate crystal depositions and extensive renal tubular damage. In the test rats, treatment with ethanolic extract of <i>T. procumbens</i> decreased the elevated levels of urinary calcium, oxalate and creatinine and significantly lowered renal deposition of calcium and oxalate. Substantial reduction in oxidative stress was also noticed. Renal histology showed considerable reduction in calcium oxalate crystal depositions. Our study results suggest that <i>T. procumbens</i> is endowed with antiurolithiatic and antioxidant activities.