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http://nopr.niscpr.res.in/handle/123456789/15939| Title: | X-ray crystal structure of the cytotoxic planar Ni(II) complex of 4N-dimethy 1-2-acetylpyridine thiosemicarbazone |
| Authors: | Murugkar, Anupa Bendre, Ratnamala Padhye, Subhash Groy, Thomas |
| Issue Date: | Oct-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Transition metal complexes of thiosemicarbazone ligands are emerging as a new class of non-platinum experimental anticancer chemotherapeutic compounds. 1-3 The observed cytotoxicities of the active complexes have been thought to arise from their interaction with intracellular thiols such as glutathiones (GSH) generating a thiolato Complex of the type [ML]+ which in turn is capable of promoting redox reactions with other thiols and oxygen generating the disulphide species (GSSG) alongwith superoxide and hydroxyl radicals. 4 The other possibility involves the binding of the drug to the enzyme, viz., ribonucleotide reductase, an obligatory enzyme for DNA synthesis, thereby hindering or blocking the DNA replication. |
| Page(s): | 981-984 |
| Appears in Collections: | IJC-A Vol.38A(10) [October 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCA 38A(10) 981-984.pdf | 1.91 MB | Adobe PDF | View/Open |
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