Electrochemical oxidation of 6-hydroxy-2,4,5- triaminopyrimidine at pyrolytic graphite electrode

Abstract

<span style="font-size:12.0pt;font-family:" times="" new="" roman","serif";="" mso-fareast-font-family:calibri;mso-fareast-theme-font:minor-latin;mso-ansi-language:="" en-in;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">The electrochemical oxidation of 6-hydroxy-2,4,5-triaminopyrimidine (<b style="mso-bidi-font-weight: normal">I</b>) at pyrolytic graphite electrode has been studied in phosphate buffers of <i style="mso-bidi-font-style: normal">p</i>H range 2.5-10.8. Under cyclic voltammetric conditions, the 2e, 2H⁺ oxidation of this compound is found to give alloxan, which has been characterized on the basis of IR, mass and NMR spectral data. The kinetics of the decay of the UV -absorbing intermediate generated during electrooxidation of compound (<b style="mso-bidi-font-weight:normal">I</b>) has been studied and first order rate constants for the disappearance of UV -absorbing intermediate have been calculated. A tentative mechanism in which electrode reaction is followed by chemical steps (EC) for the oxidation of <b style="mso-bidi-font-weight: normal">I</b> has also been suggested.</span>