Intravenous human umbilical cord blood improves elctrophysiological and metabolic properties in ISO induced myocardial necrosis in rats

Abstract

<span style="font-size:9.0pt;mso-bidi-font-size:11.0pt;mso-bidi-font-weight:bold" lang="EN-GB">Rats treated with isoproterenol (ISO, 85 mg/kg, sc, twice at an interval of 24 h) showed a significant increase in heart rate, mean arterial blood pressure, pressure rate index, ST elevation on ECG, and a significant increase in the levels of cardiac marker enzymes- lactate dehydrogenase, and creatine kinase in serum and a significant reduction in superoxide dismutase, and catalase and increase in thiobarbituric acid reactive substance activity in heart tissue. Treatment with <span style="font-size:9.0pt;mso-bidi-font-size: 11.0pt" lang="EN-GB">Human umbilical cord blood<span style="mso-bidi-font-weight:bold"> (hUCBC; 500 and 1000 µL<span style="mso-bidi-font-weight:bold">, iv, via the tail vein; 2 h after the second dose of ISO<span style="mso-bidi-font-weight: bold">) significantly restored back to normal levels and showed a lesser degree of cellular infiltration and infarct size in histopathological and planimetry studies respectively. Thus, hUCBC<i> </i>ameliorates cardiotoxic effects of isoproterenol <span style="mso-bidi-font-weight:bold">and may be of value in the treatment of myocardial infarction.

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