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http://nopr.niscpr.res.in/handle/123456789/16126| Title: | Protective effect of lawsone on L-Arginine induced acute pancreatitis in rats |
| Authors: | Biradar, Sandeep Veeresh, B |
| Keywords: | Acute pancreatitis;Anti-inflammatory;Cytokines;L-arginine;Lawsone |
| Issue Date: | Mar-2013 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The efficacy of lawsone against L-arginine induced acute pancreatitis was determined at 24 h by determination of serum levels of amylase, lipase and proinflammatory cytokines [tumor necrosis factor (TNF)-α, C-reactive proteins and interleukin (IL)], pancreatic myeloperoxidase (MPO) activity, lipid peroxidation (thiobarbituric acid reactive substances (TBARS)], nitrate/nitrite levels, and the wet weight/body weight ratio. Lawsone and methylprednisolone treatments significantly attenuated the L-arginine- induced increases in pancreatic wet weight/body weight ratio, and decreased the serum levels of amylase and lipase, and TNF-α and IL-6 and significantly lowered pancreatic levels of MPO, TBARS, and nitrate/nitrite. The histoimmunological findings further proved the amelioration of pancreatic injury by lawsone and further proved anti-inflammatory and antioxidant agent property of lawsone. |
| Page(s): | 256-261 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.51(03) [March 2013] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 51(3) 256-261.pdf | 279.25 kB | Adobe PDF | View/Open |
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