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http://nopr.niscpr.res.in/handle/123456789/16184| Title: | Chemo-enzymatic synthesis of chiral 3-hydroxy-azetidin-2-ones |
| Authors: | Bari, S S Madan, S Sethi, M K |
| Issue Date: | Jan-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | n-Tributyltin hydride reduction of 3-acetoxy-4,4-bis(alkylthio)-azetidin-2-ones 4a and 4b produces 4-unsubstituted azetidinone 5 and 4-alkylthio-azetidin-2-one 9 respectively. Azetidin-2,3-diones 8,11,13 which can be conveniently prepared by basic hydrolysis of 3-acetoxy-azetidin-2-ones 5,9,4c followed by oxidation, on biocatalytic reduction with fermenting and immobilised Baker's Yeast in aqueous and organic media, respectively affords chiral 3-hydroxy-azetidin-2- ones 6,10,12,14 with high level of enantioselectivity. |
| Page(s): | 10-17 |
| Appears in Collections: | IJC-B Vol.38B(01) [January 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(1) 10-17.pdf | 2.04 MB | Adobe PDF | View/Open |
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