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http://nopr.niscpr.res.in/handle/123456789/16204| Title: | Synthesis and antimicrobial activity of novel 4H-pyrano[2,3-f]indole derivatives† |
| Authors: | Gadaginamath, Guru S Kavali, Rajesh R |
| Issue Date: | Feb-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 5-Hydroxyindoles 1a-b have been subjected to regioselective Friedel-Craft 's acetylation to secure 3,6-diacetyl-5- hydroxyindoles 2a-b which on condensation with benzoic acids by using pyridine and phosphorous oxychloride furnish the required esters 3a-f in good yields. These esters 3a-f are subjected to Baker-Venkataraman transfomlations to obtain 3- acetyl-6-benzoylacetyl-5-hydroxyindoles 4a-f which are refluxed in AcOH and conc. HCI to afford the novel 2-phenyl-4H-pyrano[ 2,3-f]indol-4-one derivatives 5a-f. Similarly when 4a-f are heated with Ac2O and AcONa new 2-methyl-3-benzoyl-4H-pyrano[2,3-f]indol-4-one derivatives 6a-f are obtained. All these new compounds have been screened for their antibacterial and antifungal activities. |
| Page(s): | 178-182 |
| Appears in Collections: | IJC-B Vol.38B(02) [February 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(2) 178-182.pdf | 977.39 kB | Adobe PDF | View/Open |
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