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http://nopr.niscpr.res.in/handle/123456789/16217| Title: | Chemoselectivity of indole-dicarboxylates towards hydrazine hydrate: Part III - Synthesis and antimicrobial activity of novel 4-thiazolidinonylindoles |
| Authors: | Gadaginamath, G S Shyadligeri, A S Kavali, R R |
| Issue Date: | Feb-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Exclusive formation of 3-carbethoxyindol-5-yloxyacetic acid hydrazides 3a,b from 3-carbethoxy-5- ethoxycarbonylmethoxyindoles 2a,b reveals the chemoselectivity of the C5-methyl ester function towards the nucleophilic attack of hydrazine hydrate. These mono hydrazides 3a,b on reacting with benzaldehydes furnish 1-alkyl-5- benzalhydrazinocarbonylmethoxy-3-ethoxycarbonyl-2-methylindoles 5a-h which on treatment with thioglycolic acid afford the desired 1-alkyl-3-ethoxycarbonyl-2-methyl-5-[(2-phenyl-4-thiazolidinon-3-yl)aminocarbonylmethoxy] indoles 6a-h. All the new compounds have been screened for their antibacterial and antifungal activities. |
| Page(s): | 156-159 |
| Appears in Collections: | IJC-B Vol.38B(02) [February 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(2) 156-159.pdf | 896.69 kB | Adobe PDF | View/Open |
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