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http://nopr.niscpr.res.in/handle/123456789/16227| Title: | Synthesis and antimicrobial activity of novel 5-tetrazolyl/oxadiazolyl/benzimidazolylmethoxyindole derivatives |
| Authors: | Gadaginamath, Guru S Shyadlingeri, Ashok S Kavali, Rajesh R |
| Issue Date: | Feb-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 1-Alkyl-3-acetyl-2-methylindol-5-yloxyacetonitriles 2a,b, prepared by reacting 5-hydroxyindoles 1a,b with chloroacetonitrile have been converted to 1,2,3,4-tetrazolylindoles 3a,b using NaN3. LiCI and NH4C1 in dry dimethylformamide. Conversion of tetrazolylindoles 3a,b into 1,3,4-oxadiazolylindoles 4a,b has been achieved by heating with acetic anhydride. Hydrolysis of 1-alkyl-3-ethoxycarbonyl-5-ethoxycarbonylmethoxy-2-methylindoles 5a,b with ethanolic NaOH gives the corresponding diacids 6a,b, which on heating with o-phenylenediamine in 6N HCI undergo condensation with concomitant decarboxylation to yield the 1-alkyl-5-(benzimidazol-2-ylmethoxy)-2- methylindoles 7a,b. The newly synthesised bisheterocycles have been screened for their antibacterial and antifungal activities. |
| Page(s): | 188-191 |
| Appears in Collections: | IJC-B Vol.38B(02) [February 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(2) 188-191.pdf | 915.4 kB | Adobe PDF | View/Open |
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