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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Velmurugan, R | - |
| dc.contributor.author | Vijayasankar, A V | - |
| dc.contributor.author | Sekar, M | - |
| dc.date.accessioned | 2013-03-07T11:45:29Z | - |
| dc.date.available | 2013-03-07T11:45:29Z | - |
| dc.date.issued | 2013-03 | - |
| dc.identifier.issn | 0975-0983(Online); 0376-4699(Print) | - |
| dc.identifier.uri | http://hdl.handle.net/123456789/16256 | - |
| dc.description | 414-421 | en_US |
| dc.description.abstract | Microwave assisted condensation of urea, thiourea and hydrazine hydrate with 1-chloro-2-formyl carbazoles in the presence of PTSA as catalyst yields 1,11H-pyrimido[4,5-a]carbazol-2-ones, 1,11H-pyrimido[4,5-a]carbazol-2-thiones and pyrazolo[3,4-a]carbazoles, respectively. The structures of the synthesized compounds have been confirmed on the basis of elemental analysis and spectral data. All the synthesized compounds have been evaluated for their antibacterial and antifungal activities. Some of the synthesized compounds 2a-g and 3a-g exhibit significant antibacterial activity against Escherichia coli and Pseudomonas aeruginosa. The compounds 2a-g and 3a-g exhibit good antifungal activity against Candida albicans, Aspergillus flavus. Pyrazolo[3,4-a]carbazoles 4a-g register good antibacterial activity against Escherichia coli and Pseudomonas aeruginosa. The compound 4e indicate maximum activity of 20 and 24 mm at 500 and 1000µg/disc, respectively, against Lipomyces lopofera fungi. | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | NISCAIR-CSIR, India | en_US |
| dc.rights |  CC Attribution-Noncommercial-No Derivative Works 2.5 India | en_US |
| dc.source | IJC-B Vol.52B(03) [March 2013] | en_US |
| dc.subject | Pyrimido carbazoles | en_US |
| dc.subject | Pyrazolo carbazoles | en_US |
| dc.subject | Antimicrobial activity | en_US |
| dc.subject | Microwave irradiation | en_US |
| dc.title | Solvent free microwave assisted synthesis and evaluation of potent antimicrobial activity of 1,11H-pyrimido[4,5-a]carbazol-2-ones, 1,11H-pyrimido [4,5-a]carbazol-2-thiones and pyrazolo[3,4-a]carbazoles | en_US |
| dc.type | Article | en_US |
| Appears in Collections: | IJC-B Vol.52B(03) [March 2013] | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 52B(3) 414-421.pdf | 324.79 kB | Adobe PDF | View/Open |
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