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http://nopr.niscpr.res.in/handle/123456789/16306| Title: | Effect of solvents on the kinetics and mechanism of the acidic and alkaline hydrolysis of hydroxamic acids |
| Authors: | Ghosh, Kallol K Krishnani, Kishore K Ghosh, Sharmistha |
| Issue Date: | Mar-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The acid catalyzed hydrolysis of N-phenylbenzohydroxamic acid (PBHA) C6H5C(=0)N(OH)C6H5 has been studied in aq. dioxane, acetone, dimethylsulphoxide, dimethylformamide, methanol, ethanol and 2-propanol mixtures. Dioxane and methanol have a rate enhancing effect but DMF, acetone, ethanol and 2-propanol exert a rate decreasing effect. In DMSO an increase is followed by a decrease i.e. a rate maximum is observed. An attempt has also been made to study the alkaline hydrolysis of PBHA and two of its derivatives (X-C6H4C(=0)N(OH)C6H5; X=4-NO2, 4-CI) in aq. dioxane. In all case the pseudo first order rate constant increase with increasing dioxane content. The activation parameters ΔH‡, ΔS‡ and ΔGH‡, have been calculated. An attempt has been made to correlate rate data for acidic hydrolysis in terms of solvatochromic parameters and linear free energy relationships. |
| Page(s): | 337-342 |
| Appears in Collections: | IJC-B Vol.38B(03) [March 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(3) 337-342.pdf | 1.4 MB | Adobe PDF | View/Open |
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