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http://nopr.niscpr.res.in/handle/123456789/16314| Title: | Synthesis and microbial activity of new thiazolyl 1,4-benzothiazines |
| Authors: | Dengle, R V Ingle, R D Bondge, S P Mane, R A |
| Issue Date: | Mar-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 5-Acyl-2-aryl-4-methyl thiazoles 1 have been converted to 1-(2' -aryl-4' -methylthiazol-5' -yl)-3-aryl-2-propen-1-ones 2 by Claisen-Schmidt condensation. The chalcones 2 are brominated to give their bromo derivatives 3 which on hydrolysis yield 1-(2'aryl- 4' -methylthiazol-5'-yl)-3-arylpropane-1,3-diones 4. The diones 4 when condensed with 2-aminobenzenethiol in refluxing DMSO furnish cyclic product, 2-aroyl-3-(2'-aryl-4'methylthiazol- 5' -yl)-4H-1,4-benzothiazines 5. The results of microbial screening of the compounds 5 have been discussed. |
| Page(s): | 390-393 |
| Appears in Collections: | IJC-B Vol.38B(03) [March 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(3) 390-393.pdf | 765.91 kB | Adobe PDF | View/Open |
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