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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Doshi, Rajeev | - |
| dc.contributor.author | Kagthara, Preeti | - |
| dc.contributor.author | Parekh, Hansa | - |
| dc.date.accessioned | 2013-03-09T11:19:02Z | - |
| dc.date.available | 2013-03-09T11:19:02Z | - |
| dc.date.issued | 1999-03 | - |
| dc.identifier.uri | http://hdl.handle.net/123456789/16325 | - |
| dc.description | 348-352 | en_US |
| dc.description.abstract | Substituted chalcones 2a-m prepared by the treatment of 5-benzoyl-benzimidazol-2-yl-o-benzoyl(4' –aminoaceto-phenone) 1 with araldehydes, on cyclisation with hydroxylamine hydrochloride in ethanol furnish isoxazoles 3a-m. The same chalcones on condensation with malononitrile yield cyanopyridines 4a-m. The structure of the compounds synthesised have been assigned on the basis of elemental analyses, IR and NMR spectral studies. Most of the compounds exhibit significant activity against Mycobacterium tuberculosis H37 Rv and MIC value is reported. Compounds 2c,3c and 4d have been selected by Merck Incorporation USA for further pharmacological screening. | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | NISCAIR-CSIR, India | en_US |
| dc.rights |  CC Attribution-Noncommercial-No Derivative Works 2.5 India | en_US |
| dc.source | IJC-B Vol.38B(03) [March 1999] | en_US |
| dc.title | Synthesis and biological evaluation of some novel isoxazoles and cyanopyridines, a new class of potential anti-tubercular agents | en_US |
| dc.type | Article | en_US |
| Appears in Collections: | IJC-B Vol.38B(03) [March 1999] | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(3) 348-352.pdf | 1.61 MB | Adobe PDF | View/Open |
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