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http://nopr.niscpr.res.in/handle/123456789/16433| Title: | Synthesis and biological activity of some D-ring modified estrone derivatives |
| Authors: | Gupta, Ranju Jindal, Dharam Paul Borras, M Legros, N Leclercq, G |
| Issue Date: | May-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 3-Methoxy-17-aza-D-homo-1,3,5(10)-estratrienc-16, 17a-dione 3, 16, 17a-dioxo-17-aza-D-homo-1,3,5(10)-estratrien-3-yl acctate 12 and a series of related compounds have been synthesised from 3-methoxy-16-oximino- 1,3,5 (10)-estrairian-17- one 1 and 3-hydroxy-16-oximino- 1,3,5 (10)-estnttrien-17-one 2, respectively. The compounds 3 (DPJ-280), 14 (DPJ-369), 17 (DPJ-370), 18 (DPJ-354), 19 (DPJ-320), 21 (DPJ- 321 ), 22 (DPJ-374) and (DPJ-284) have been evaluated for their estrogenic/antiestrogenic effects and the compounds 3-7,8,9,10,12,15,16,18,20,21,23 and 24 have been screened for antineoplastic activity at NCI, Bethesda. |
| Page(s): | 563-571 |
| Appears in Collections: | IJC-B Vol.38B(05) [May 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(5) 563-571.pdf | 2.27 MB | Adobe PDF | View/Open |
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