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http://nopr.niscpr.res.in/handle/123456789/16448| Title: | Synthesis of 2, 5-disubstituted 1, 3, 4-oxadiazoles as biologically active heterocycles |
| Authors: | Kagthara, Preeti R Shah, Niraj S Doshi, Rajeev K Parekh, H H |
| Issue Date: | May-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 2-(8enzimidazol-2'-yl) benzoyl hydrazide 1 when condensed with aromatic acids in the presence of POCI3 afforded 2-aryl -5-[2'-benzimidazol-2"-yl) phenyl]-l, 3, 4-oxadiazoles 2a-o. The acid hydrazide 1 on cyclisation with CNBr yield 2-amino-5-[2'-(benzimidazol-2 "-yl-phenyl)- 1, 3, 4-oxadiazole 3 which on reaction with aryl sulphonyl chlorides and substituted benzoyl chloride give the corresponding sulphonaillides 4a-o and amides 5a-o, respectively. All the products have been evaluated in vitro for their antimicrobial activity against several microbes and antitubercular activity against Mycobacterium tuberculosis H37Rv. |
| Page(s): | 572-576 |
| Appears in Collections: | IJC-B Vol.38B(05) [May 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(5) 572-576.pdf | 905.23 kB | Adobe PDF | View/Open |
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