Synthesis and antibacterial activity of 4-aryl-1-(1-<i style="mso-bidi-font-style:normal">p</i>-chlorophenyl-5-methyl- <span style="font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-IN;mso-fareast-language: EN-IN;mso-bidi-language:AR-SA" lang="EN-IN">1,2,3-triazol-4-carbonyl)thiosemicarbazides and their related heterocyclic derivatives</span>

Abstract

<span style="font-size:12.0pt;font-family: " times="" new="" roman";mso-fareast-font-family:"times="" roman";mso-ansi-language:="" en-in;mso-fareast-language:en-in;mso-bidi-language:ar-sa"="" lang="EN-IN">A series of new 2-arylamino-5-(1-<i style="mso-bidi-font-style:normal">p</i>-chlorophenyl-5-methyl-1,2,3-triazol-4-yl)-1 ,3,4-thiadiazoles <b style="mso-bidi-font-weight:normal">5a-d,</b> 4-aryl-3-(1-<i style="mso-bidi-font-style:normal">p</i>-chlorophenyl-5-methyl-1,2,3-triazol-4-yl)-1,2,4-triazolin-5-thiones <b style="mso-bidi-font-weight:normal">6a-e,</b> 2-arylamino-5-( 1-p-chlorophenyl-5-methyl-1.2,3-triazol-4-yl)-1 ,3,4-oxadiazoles <b style="mso-bidi-font-weight:normal">7a-d</b> have been synthesized by the intramolecular cyclization of 4-aryl-1-( 1-<i style="mso-bidi-font-style:normal">p</i>-chlorophenyl-5-methyl-1,2,3-triazol-4-carbonyl)thiosemicarbazides <b style="mso-bidi-font-weight:normal">4a-e</b> with cone. H₂S0₄, <span style="mso-bidi-font-style:italic">2<i>N </i>NaOH and NaOAc-HOAc solution, respectively. Supports for the structures of the synthesized compounds have been provided by their elemental analyses and spectral data. The representative compounds are evaluated for their antibacterial activity.</span></span>