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http://nopr.niscpr.res.in/handle/123456789/16471| Title: | Synthesis and biological activity of 2-azetidinones, sulphonamides, arylamides and thiourea derivatives |
| Authors: | Patel, Pankaj Korgaokar, Sushil Parikh, Khyati Parekh, Hansa |
| Issue Date: | Jun-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 2-Amino-4-[2-(p-chlorobenzenesulphonamido)phenyl]thiazole 1 on condensation with aromatic aldehydes afford 2-benzalamino-4-[2-(p- chlorobenzenesulphonamido)phenyl]thiazole of the type 2. The latter undergoes cyclisation with chloroacetyl chloride in the presence of triethylamine furnishing 2-(4'-aryl-3'-chloro-2'-azetidinon-1'-yl)-4-[2-(p-chlorobenzenesulphonamido) Phenyl]thiazole 3. Thiazole 1 on reaction with different arylsulphonyl chlorides, substituted benzoyl chlorides and various aryl isothiocyanates gives the corresponding 2-aryl sulphonamido-4-[2-(p-chlorobenzene-sulphonamido)phenyl]thiazoles 4, 2-aroylamino-4-[2-(p-chlorobenzenesulphonamido)phenyl]thiazoles 5 and 2- substituted arylthioureidoamino-4-[2-(p-chlorobenzene-sulphonamido)phenyl]thiazoles 6. The products display moderate to good antimicrobial and tuberculostatic activities. The structures of the products 2-6 have been elucidated by elemental analyses and spectral data. |
| Page(s): | 696-700 |
| Appears in Collections: | IJC-B Vol.38B(06) [June 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(6) 696-700.pdf | 486.77 kB | Adobe PDF | View/Open |
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