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http://nopr.niscpr.res.in/handle/123456789/16494| Title: | Synthesis of 4-thiazolidinone and 2-azetidinone derivatives of 2-trifluoromethyl- 1,8-naphthyridine as antibacterial agents |
| Authors: | Mogilaiah, K Rao, R Babu Reddy, K Narender |
| Issue Date: | Jul-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Ethyl 2-trifluoromethyl- 1,8-naphthyridine-3-carboxylate 3 has been synthesized by the condensation of 2- aminonicotinaldehyde 1 with ethyl trifluoroacetoacetate 2 and subjected to hydrazinolysis with refluxing hydrazine hydrate to give 2-trilluoromethyl-1,8-naphth yridine-3-carboxylic acid hydrazide 4. The acid hydrazide 4 reacts with aromatic aldehydes to yield the corresponding 2-trilluoromethyl -1,8-naphthyridine-3-carboxylic acid arylidenehydrazides 5. Cyclocondensation of 5 with mercaptoacetic acid in DMF in the presence of anhyd. ZnCl2 affords 2-aryl-3-(2- trifluoromethyl-1,8-naphthyridine-3-carbonylalllino)-4-thiazolidinones 6. On the other hand, cycloaddition of chloroacetyl chloride to 5 in dioxane in the presence of Et3N gives 4-aryl-3-chloro-1-(2-trilluoromethyl-1,8 -naphthyridine-3-carbonylamino)-2-azetidinones 7. These compounds have been characterized on the basis of elemental analysis. IR, 1H NMR and MS. All the products have been evaluated for antibacterial activity. |
| Page(s): | 818-822 |
| Appears in Collections: | IJC-B Vol.38B(07) [July 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(7) 818-822.pdf | 958.74 kB | Adobe PDF | View/Open |
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