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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Zimmer, Reinhold | - |
| dc.contributor.author | Grassberger, Maximilian A | - |
| dc.contributor.author | Baumann, Karl | - |
| dc.contributor.author | Zenke, Gerhard | - |
| dc.contributor.author | Schuler, Walter | - |
| dc.date.accessioned | 2013-03-27T19:42:28Z | - |
| dc.date.available | 2013-03-27T19:42:28Z | - |
| dc.date.issued | 1999-07 | - |
| dc.identifier.uri | http://hdl.handle.net/123456789/16502 | - |
| dc.description | 831-834 | en_US |
| dc.description.abstract | A short transformation of 22(R)-dihydro-iso-ascomycin to novel 19, 20-seco-iso-ascomycin derivatives is described. The biological activity of the new compounds is compared with that of standards in assays relevant for ascomycin/FK 506 type compounds (macrophilin-12 binding assay, IL-2 reporter gene assay). The results indicate that the 19, 20-seco-derivative 3 might develop into a key intermediate for the synthesis of new derivatives with interesting biological activities. | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | NISCAIR-CSIR, India | en_US |
| dc.rights |  CC Attribution-Noncommercial-No Derivative Works 2.5 India | en_US |
| dc.source | IJC-B Vol.38B(07) [July 1999] | en_US |
| dc.title | Synthetic modifications of ascomycin : Part III1 - A concise transformation of iso-ascomycin to 19, 20-seco-derivatives | en_US |
| dc.type | Article | en_US |
| Appears in Collections: | IJC-B Vol.38B(07) [July 1999] | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(7) 831-834.pdf | 723.68 kB | Adobe PDF | View/Open |
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