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http://nopr.niscpr.res.in/handle/123456789/16576| Title: | Design and synthesis of aroylbenzodifurans as anti-implantation agents |
| Authors: | Murthy, K S Krishna Kumari, Y Ratna Rajitha, B Rao, M Kanakalingeswara Dhar, (Mrs) J D Setty, B S |
| Issue Date: | Aug-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Bisaroylbenzodifurans namely, 3, 5-dimethyl-2, 6-dibenzoyl-(3a); 2, 6-di(4-methylbenzoyl)-(3b); 2, 6-di(4-chlorobenzoyl-(3c); 2,6-di(4-bromobenzoyl)-(3d); 2, 6-di-(4-nitrobenzoyl)-(3e); 2, 6-di-(4-phenylbenzoyI)-(3f) and 2, 6-di-(4- methoxybenzoyl)-(3g)-benzo[1,2-b: 5,4-b'] difurans have been synthesized by condensing resdiacetophenone with phenacyl bromide in (a) baked K2CO3,-dry acetone and (b) under phase transfer catalytic conditions. A comparison has been made between the two methods. PTC procedure is observed as an effective route for the synthesis of bisaroyl benzodifurans. All the seven compounds are screened for anti-implantation activity. 3a is found to be active in preventing implantation in albino rats at 2 mg/kg/rat/day. |
| Page(s): | 938-941 |
| Appears in Collections: | IJC-B Vol.38B(08) [August 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(8) 938-941.pdf | 819.76 kB | Adobe PDF | View/Open |
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