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http://nopr.niscpr.res.in/handle/123456789/16579| Title: | 9+9+9Synthesis of N,N'-bis(4-methyloxazol-5-yl)-urea as the key building block of 1,3-bis(4-methyloxazol-5-yl)xanthine towards an improved bronchodilator |
| Authors: | Ray, Sibdas Ghosh, Sukla |
| Issue Date: | Aug-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 4-Methyloxazole-5-carboxylic acid 2 is converted to 4-methyloxazol-5-yl carboxazide 3 in a one-pot reaction with ethyl chloroformate and triethylamine in cold followed by treatment with sodium azide. 3 is transformed to 4-methyloxazol-5-yl isocyanate 4 by heating in dry benzene. 4, on reaction with aqueous sodium hydroxide in the presence of benzyltriethylammonium chloride and dichloromethane furnish N,N'-bis(4-methyloxazol-5-yl)urea 5, as the key building block of the theophylline analogue, 1,3-bis(4- methyloxazol-5-yl)xanthine, a possible improved bronchodialator. 13C NMR spectral intricacies of the oxazole ring system as an electron withdrawing unit have been discussed. |
| Page(s): | 986-988 |
| Appears in Collections: | IJC-B Vol.38B(08) [August 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(8) 986-988.pdf | 739.81 kB | Adobe PDF | View/Open |
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