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http://nopr.niscpr.res.in/handle/123456789/16583| Title: | Mass spectrometer as a probe in the synthesis of 2-substituted-4(3H)-quinazolinones |
| Authors: | Ramana, D V Sundaram, N Yuvaraj, T Eswara Babu, B Ganesh |
| Issue Date: | Aug-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The ortho interaction of the amide function with the N-aroyl group in 2-(substituted benzamido)benzamides 1-11 on electron impact leads to the elimination of H2O from the molecular ions, albeit a minor process, resulting in the formation of 2-substituted-4(3H)-quinazolinone radical cations. The mechanisms and ion-structure, proposed in the mass spectral study, are supported by high resolution data, Collision Activated Decomposition (CAD)-B/E-linked scan spectra and CAD MIKE spectrum. This mass spectrometry reaction has been fruitfully exploited in the laboratory to synthesise 4(3H)-quinazolinones 13-23 in excellent yields by the pyrolysis of 2-(substituted benzamido)benzamides. |
| Page(s): | 905-908 |
| Appears in Collections: | IJC-B Vol.38B(08) [August 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(8) 905-908.pdf | 838.46 kB | Adobe PDF | View/Open |
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