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http://nopr.niscpr.res.in/handle/123456789/16596| Title: | Synthesis and antibacterial activities of 1,3,4-thiadiazole, 1,3,4-oxadiazole and 1,2,4-triazole derivatives of 5-methylisoxazole |
| Authors: | Hui, Xin-Ping Zhang, Lin-Mei Zhang, Zi-Yi Wang, Qin Wang, Fang |
| Issue Date: | Sep-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A series of 5-(5-methylisoxazol-3-yl)- 1,3,4-thiadiazoles 3a-d, 1,2,4- triazoles 4,5 and 1,3,4-oxadiazoles 7, 8, 9 have been synthesized from 5-methylisoxazol-3-acetic acid hydrazide 1 via N4-aroyl- N4-(5-methylisoxazol-3-formyl) thiosemicarbazides 2a-h and N1-(5-methylisoxazol-3-carbonyl)- N4 -phenyl semicarbazide 6. The thiosemicarbazides 2a-h and semicarbazide 6 have been readily obtained from 5-methylisoxazol-3-acetic acid hydrazide 1 in good yield. Structures of the compounds have been established on the basis of elemental analyses and spectral data. Some of them have been screened for antibacterial activities. |
| Page(s): | 1066-1069 |
| Appears in Collections: | IJC-B Vol.38B(09) [September 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(9) 1066-1069.pdf | 921.51 kB | Adobe PDF | View/Open |
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